The Library holds a 10,000 year lease on the eleventh floor of the Mercantile Library Building at 414 Walnut Street, Cincinnati. The lease was issued by The Cincinnati College, from which the University of Cincinnati College of Law descended. The Library paid $10,000 to commission a suite of rooms on the second floor of a new building following the destruction by fire of the original building in 1845.

The library's present home is divided into a reading room and bi-level stacks. These quarters were especially designed for the library in l903 by the Thomas Emery firm, developers of the present building. Most of the bookshelves and furnishings in the reading room are from the library's previous quarters.